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US 12,441,762 B2Granted
Hepatitis c virus NS3/4A protease inhibitors
AssigneeUniversity of Massachusetts
InventorsCelia A. Schiffer, Akbar Ali, Jacqueto Zephyr, Ashley N. Matthew, Nageswara R. Desaboini
Life of this patent
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Abstract
The invention provides novel classes of HCV therapeutics that are orally available, safe and effective HCV NS3/4A protease inhibitors and are less susceptible to drug resistance than existing therapeutics. The invention also relates to pharmaceutical composition of these compounds and methods of preparation and use thereof.
Claims5
A compound having the structural formula (Ia),
- wherein
- R1 is R′;
- R is a C3-C6 cyclic alkyl group;
- and
- R′ is a C1-C3 alkyl.
2 more elements
A compound having the structural formula (I),
- wherein Rcap is selected from:
Dependencies are inferred from the claim text.