Processes and compounds

A process of preparing a compound of formula (VIII)

• comprising the reduction of a compound of formula (VII)
• wherein said compound of formula (VII) is prepared by a reductive amination of a compound of formula (VI)
• in the presence of a compound of formula (f)
• wherein said compound of formula (VI) is prepared by contacting a compound of formula (V)
• with a chiral acid to form an enantiomerically enriched salt, crystallizing the enantiomerically enriched salt, and freeing the compound of formula (VI),
• wherein said compound of formula (V) is prepared by treatment of a compound of formula (IV) with an acid, base, or reducing agent;
• wherein said compound of formula (IV) is prepared by reduction of a compound of formula (III)
• wherein said compound of formula (III) is prepared by the coupling of a compound of formula (I)
• with a compound of formula (II)
• and wherein P1 is H, or a phenol protecting group;
• Rb is H or Et;
• P2 is (C═O)—CH3;
• X is a halogen, transition metal or boron-containing compound;
• and X′ is a halogen, transition metal-containing function or boron-containing function;
• and wherein said X and X′ are suitable for cross-coupling of compound (I) with compound (II).