N/O-linked degrons and degronimers for protein degradation

A compound of Formula:

• or a pharmaceutically acceptable salt thereof;
• wherein:
• n is 0, 1, or 2;
• R4 is selected at each instance from C1-6-alkyl, hydroxyl, C1-6-alkoxy, amino, —NHC1-6-alkyl, —N(C1-6-alkyl)2, and C1-6-haloalkyl;
• R5 is selected at each instance from C1-6-alkyl, halogen, hydroxyl, C1-6-alkoxy, amino, cyano, —NH(C1-6-alkyl), —N(C1-6-alkyl)2, —C(O)R4, and C1-6-haloalkyl;
• R12 is Linker-H;
• Linker is selected from:
• wherein:
• Heteroaryl is a 5- or 6-membered heteroaryl containing 1 or 2 heteroatoms selected from nitrogen, oxygen, and sulfur;
• Aryl is phenyl;
• Heterocycle is a 4- to 6-membered heterocycle containing 1 to 4 nitrogen atoms, 1 to 2 oxygen atoms and 1 to 3 nitrogen atoms, or 1 to 2 sulfur atoms and 1 to 3 nitrogen atoms;
• X1 and X2 are independently selected from bond, NH, NR25, CH2, CHR25, C(R25)2, O, and S;
• R20, R21, R23, and R24 are independently selected from bond, C1-6-alkyl, —C(O)—, —O—, —NH—, —N(C1-6-alkyl)-, C2-6-alkene, C1-6-haloalkyl, C2-6-alkyne, phenyl, 4- to 6-membered heterocycle containing 1 to 4 nitrogen atoms, 1 to 2 oxygen atoms and 1 to 3 nitrogen atoms, or 1 to 2 sulfur atoms and 1 to 3 nitrogen atoms, and 5- or 6-membered heteroaryl;
• each of which R20, R21, R23, and R24 is optionally substituted with one substituent independently selected from R101;
• R101 is independently selected at each occurrence from hydrogen, C1-6-alkyl, C1-6-haloalkyl, C1-6-alkoxy, hydroxyl, phenyl, 5- or 6-membered heteroaryl, 4- to 6-membered heterocycle containing 1 to 4 nitrogen atoms, 1 to 2 oxygen atoms and 1 to 3 nitrogen atoms, or 1 to 2 sulfur atoms and 1 to 3 nitrogen atoms, CN, —C(O)OC1-6-alkyl, C(O)OH NO2, F, Cl, Br, NH2, NHC1-6-alkyl, and N(C1-6-alkyl)2;
• and
• R25 is selected at each instance from C1-6-alkyl, —C(O)H, —C(O)OH, —C(O)C1-6-alkyl, and —C(O)OC1-6-alkyl.