US 12,441,734 B2 · Ferroptosis inhibitor and use therefor

Abstract

The present invention provides a means whereby it is possible to clarify the mechanism of manifestation of symptoms, an illness, or dysfunction caused by mitochondrial dysfunction and prevent or treat symptoms, an illness, or dysfunction relating to the same mechanism of manifestation. One embodiment of the present invention relates to a ferroptosis inhibitor containing a compound represented by formula (I), a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof as an active ingredient. Another embodiment of the present invention relates to a medicine that contains the ferroptosis inhibitor as an active ingredient and is for use in the prevention or treatment of symptoms, an illness, or dysfunction relating to ferroptosis. Yet another embodiment of the present invention relates to a compound represented by formula (I-1), a salt thereof, or a solvate thereof.

Claims13

Dependent claims

A compound represented by the formula (I-1):

wherein
RN1 is methyl,
R1 is hydrogen,
both R2 and R3 are hydrogen,
R4 is hydroxyl,
R5 is selected from the group consisting of unsubstituted C1 to C9 alkoxy, C1 to C9 alkoxy substituted by at least one monovalent group selected from the group consisting of halogen, hydroxyl, and carboxyl, unsubstituted C7 to C20 arylalkyloxy, and C7 to C20 arylalkyloxy substituted by at least one monovalent group selected from the group consisting of halogen, hydroxyl, and carboxyl, with the proviso that methoxy and benzyloxy are excluded from R5, and
both R6 and R7 are hydrogen,
or a salt thereof, or a solvate of the compound or the salt.

5 more elements

Dependencies are inferred from the claim text.

Ferroptosis inhibitor and use therefor

Life of this patent

Ferroptosis inhibitor and use therefor

Life of this patent

Abstract

Claims13