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US 12,441,710 B2Granted
Substituted piperidino compounds and related methods of treatment
AssigneeAlkermes, Inc.
InventorsLewis D. Pennington, Younggi Choi, Hoan Huynh, Brian M. Aquila, Ingo Andreas Mugge, Yuan Hu, James R. Woods, Brian Kenneth Raymer, Jörg Martin Bentzien, Jonathan Ward Lehmann, Srinivasa Karra, Roman A. Valiulin, Daljit Matharu
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Abstract
The present invention provides compounds useful for the treatment of narcolepsy or cataplexy in a subject in need thereof. Related pharmaceutical compositions and methods are also provided herein.
Claims47
A compound of Formula I-A or a pharmaceutically acceptable salt thereof:
- wherein:
- T is CR6 or N;
- U is CR5 or N;
- V is CR4 or N;
- W is CR3 or N;
- X is CR2 or N;
- and provided that
- includes no more than 3 nitrogen atoms in the ring;
- E is selected from the group consisting of NRaRb, C1-C3 alkylene-NRaRb, C1-C3 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, C3-C8 cycloalkyl, C1-C3 alkylene-(C3-C8 cycloalkyl), 4- to 10-membered heterocyclyl, and C1-C3 alkylene-(4 to 10-membered heterocyclyl) wherein the C1-C3 alkylene-NRaRb, C1-C3 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, C3-C8 cycloalkyl, C1-C3 alkylene-(C3-C8 cycloalkyl), 4- to 10-membered heterocyclyl, or C1-C3 alkylene-(4 to 10-membered heterocyclyl) is unsubstituted or substituted with one or more halogen, hydroxyl, C1-C3 alkyl, or C1-C3 alkoxyl;
- Ra and Rb are each, independently, H or unsubstituted C1-C3 alkyl;
- R1 is (CRcRd)n-(C6-C10 aryl) or (CRcRd)n-(5 to 10-membered heteroaryl) wherein the aryl or heteroaryl is unsubstituted or substituted with one or more halogen, hydroxyl, unsubstituted C1-C3 alkyl, or C1-C3 alkyl substituted with one or more halogen or deuterium;
- Rc and Rd are each, independently, H, unsubstituted C1-C3 alkyl, or C1-C3 alkyl substituted with one or more halogen or deuterium;
- n is 0 or 1;
- each of R2, R3, R4, R5, and R6, when present, is, independently, selected from the group consisting of H, halogen, deuterium, hydroxyl, cyano, unsubstituted C1-C3alkyl, and C1-C3alkyl substituted with one or more halogen or deuterium;
- each of R7, R8, R9, R10, R11, R12, and R13 is, independently, H, halogen, unsubstituted C1-C3 alkyl, or C1-C3 alkyl substituted with one or more halogen or deuterium;
- or, alternatively, R8 and R11, together form an unsubstituted C1-C3 alkylene or a C1-C3 alkylene substituted with one or more halogen;
- or, alternatively, R9 and R10, together form an unsubstituted C1-C3 alkylene or a C1-C3 alkylene substituted with one or more halogen;
- p is 0, 1, 2, 3, or 4;
- and
- each R14 is, independently, selected from the group consisting of deuterium, halogen, hydroxyl, and cyano.
17 more elements
Dependencies are inferred from the claim text.