Process for preparation of triazole compound
AssigneeUpl Ltd
InventorsJignesh Amrutlal Desai, Digish Manubhai Panchal
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Abstract
Processes for preparation of a high purity cyproconazole, i.e., (2RS,3RS;2RS,3SR)-2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl) butan-2-ol; and its compound i.e., 2-(4-chlorophenyl)-2-(1-cyclopropylethyl) oxirane generally includes reacting a ketone of formula (II) with a sulfonium salt in the presence of a base to obtain the oxirane compound of formula (III); wherein the sulfonium salt is obtained by reacting dimethyl sulfide and dimethyl sulfate in the presence of water; followed by reacting the oxirane compound of formula (III) with 1,2,4-triazole or its alkali metal salt to obtain a crude cyproconazole; and treating the crude cyproconazole with an aqueous alcohol to obtain a higher purity cyproconazole.
Claims10
A process for preparing high purity cyproconazole of formula (I),
- the process, free of column chromatography, comprising:
- a) reacting a ketone of formula (II) with a sulfonium salt in the presence of a base to obtain a compound of formula (III);
- wherein the sulfonium salt is obtained by reacting dimethyl sulfide and dimethyl sulfate in the presence of water;
- b) reacting the compound of formula (III) with 1,2,4-triazole or its alkali metal salt to obtain a crude cyproconazole;
- and
- c) treating the crude cyproconazole with an aqueous alcohol to obtain the high purity cyproconazole.
Dependencies are inferred from the claim text.