Drp1-filamin complex formation inhibitors
AssigneeRDiscovery, LLC
InventorsAkio Ojida, Naoya Shindo, Akiyuki Nishimura, Motohiro Nishida
Life of this patent
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Abstract
Compounds represented by formula (I) below and pharmacologically acceptable salts thereof and solvates of them; pharmaceutical compositions and dynamin-related protein 1 (Drp1)-filamin complex formation inhibitors containing them; and uses of the compounds, salts, solvates, pharmaceutical compositions, and (Drp1)-filamin complex formation inhibitors for use as a prophylactic or therapeutic agent.
Claims93
A compound of Formula (I):
- or a pharmacologically acceptable salt thereof or a solvate of them, wherein:
- R1 is phenyl substituted with one to three substituents each of which is independently NO2, NH2, OH, C1-C6 alkyl, C1-C6 haloalkyl, or C1-C6 alkoxyalkyl, provided that at least one substituent is NO2 or NH2;
- R2 is H, C1-C6 alkyl, C1-C6 haloalkyl, or C1-C6 alkoxyalkyl;
- R3 is H, C1-C6 alkyl, C1-C6 haloalkyl, or C1-C6 alkoxyalkyl;
- R4 is C1-C6 alkyl or C1-C6 haloalkyl;
- R5 is phenyl or pyridinyl, wherein the phenyl or pyridinyl is unsubstituted or substituted with one to three substituents each of which is independently NO2, NH2, OH, C1-C6 alkyl, C1-C6 haloalkyl, or C1-C6 alkoxyalkyl;
- either (i) bond a is present and bonds b and c are absent or (ii) bonds b and c are present and bond a is absent;
- A is NH when bond a is present and N when bonds b and c are present;
- m is an integer from 1 to 4;
- and
- n is an integer from 1 to 3;
- provided that the compound is other than
A compound represented by Formula (1) below or a pharmacologically acceptable salt thereof or a solvate of them:
- wherein in Formula (1), R1 represents a phenyl group, 2-pyridyl group, 3-pyridyl group or 4-pyridyl group, R2 represents a hydrogen atom or amino group, R3 represents a hydrogen atom or nitro group, and if R2 is a hydrogen atom then R3 is a nitro group, and, if R2 is an amino group then R3 is a hydrogen atom.
A compound represented by Formula (2) below or a pharmacologically acceptable salt thereof or a solvate of them:
- wherein in Formula (2), R4 represents a phenyl group, 2-pyridyl group, 3-pyridyl group or 4-pyridyl group, R5 represents an amino group, and R6 represents a hydrogen atom.
A compound of Formula (A):
- or a pharmacologically acceptable salt thereof or a solvate of them, wherein:
- (a) R is NO2 or NH2, wherein R is at the 2-position, 3-position, or 4-position of the phenyl ring;
- and
- (b) X is CH or N,
- provided that the compound is other than
A compound of Formula (B):
- or a pharmacologically acceptable salt thereof or a solvate of them, wherein:
- (a) R is NO2 or NH2, wherein R is at the 2-position, 3-position, or 4-position of the phenyl ring;
- and
- (b) X represents CH or N,
- provided that the compound is other than:
Dependencies are inferred from the claim text.