Automated chromatography column switching control based on pressure detection
AssigneeCytiva Sweden AB
InventorKarol Maciej Lacki
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Abstract
Certain embodiments of the invention provides a method for monitoring level of saturation of a chromatography media in a column, which method comprises measuring a first pressure at the inlet of an unloaded column; measuring a second pressure at the inlet from a loaded column; and comparing the first and second pressure measurement of determine the level of saturation of the chromatography media. Embodiments of the invention also provide related methods for controlling a chromatography system and methods for controlling a periodic counter current chromatography system, as well as a chromatography system suitable for use with the novel methods.
Claims10
A method for monitoring a level of saturation of a chromatography media in a column, which method comprises:
- measuring a first pressure at the inlet of an unloaded column;
- measuring a second pressure at the inlet from a loaded column;
- comparing the first and second pressure measurement to determine the level of saturation of the chromatography media;
- and
- determining whether the level of saturation has reached a saturation point level in the loaded column in which a feed is disposed, and, if the saturation point level is reached, redirecting the feed to a different column.
Dependencies are inferred from the claim text.