Systems and methods for phototherapeutic modulation of nitric oxide
AssigneeKNOW Bio, LLC
InventorsNathan Stasko, Nicholas William Medendorp, Jr., Gerald H. Negley, Katelyn P. Reighard
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Abstract
Systems and methods for phototherapeutic modulation of nitric oxide in mammalian tissue include use of a first wavelength and first radiant flux of light to stimulate enzymatic generation of nitric oxide, and use of a second wavelength and second radiant flux of light to stimulate release of nitric oxide from endogenous stores of nitric oxide. Pulsed light and/or partially non-overlapping light impingement windows may be used. Non-coherent light impinged on tissue may include a peak wavelength in a range of from 410 nm to 440 nm in the absence of light emissions having a peak wavelength of from 600 nm to 900 nm.
Claims15
A method comprising:
- impinging light having a first peak wavelength on tissue during a first time window, and an intensity of the light having the first peak wavelength decreases to a reduced non-zero value during the first time window;
- impinging light having a second peak wavelength on the tissue during a second time window;
- and
- impinging light having a third peak wavelength on the tissue;
- wherein the second peak wavelength differs from the first peak wavelength by at least 25 nanometers (nm);
- wherein the third peak wavelength differs from each of the first peak wavelength and the second peak wavelength by at least 10 nm;
- and
- wherein the first time window and the second time window are non-overlapping with one another, and the first time window is devoid of the second peak wavelength.
Dependencies are inferred from the claim text.