Biocompatible, flexible, haemostatic sheet

Abstract

Biocompatible, flexible, haemostatic sheets are provided comprising a water-resistant cohesive fibrous carrier structure comprising a three-dimensional interconnected interstitial space and fibres comprising a nucleophilic polymer carrying reactive nucleophilic groups; and distributed within the interstitial space throughout the fibrous carrier structure, a plurality of reactive polymer particles comprising a water-soluble electrophilic polymer carrying at least three reactive electrophilic groups that are capable of reacting with both amine groups in tissue and blood and with the reactive nucleophilic groups of the nucleophilic polymer to form covalent bonds, wherein the reactive polymer particles have a diameter between 0.5-100 μm and are present in an amount of at least 3% by weight of the fibrous carrier structure.

Dependencies are inferred from the claim text.