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US 12,440,587 B2Granted
Particles functionalized with imageable radioisotopes and methods of making and use thereof
AssigneesBoston Scientific Medical Device Limited, University of Virginia Patent Foundation
InventorsJames Radford Stone, Kiel Douglas Neumann, Matthew Robert Dreher
Life of this patent
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Abstract
Some embodiments relate to imageable radioisotopic microspheres. In some embodiments, the imageable microspheres are radiolabeled with imageable radioisotopes. In some embodiments, the imageable radioisotope is directly coupled to a surface of a substrate of the microsphere. In some embodiments, the imageable microspheres can be used as surrogate particles to predict the distribution of therapeutic microspheres comprising radiotherapeutic isotopes.
Claims18
A method for determining an amount of therapeutic microspheres to provide to a body of a patient, the method comprising:
- delivering a population of imageable microspheres to the patient by introducing the population of imageable microspheres to a first position in a vasculature of the patient;
- allowing the population of imageable microspheres to distribute within the body of the patient;
- determining a distribution of at least a portion of the population of the imageable microspheres within the body of the patient by imaging a portion of the body of the patient using an imaging modality;
- and
- using the distribution of the imageable microspheres to calculate an amount of therapeutic microspheres to be delivered to the body of the patient;
- the imageable microspheres comprising a substrate and at least one imageable radioisotope bound to a surface of the substrate;
- wherein the substrate comprises silicon dioxide and at least one other element selected from manganese, aluminum, gallium, yttrium, boron, strontium, and titanium;
- wherein the at least one imageable radioisotope is selected from 99mTc, 201Th, 51Cr, 67Ga, 68Ga, 111In, 64Cu, 89Zr, 59Fe, 42K, 82Rb, 24Na, 45Ti, 44Sc, 51Cr, 177Lu, 18F, and/or combinations thereof;
- and
- wherein the at least one imageable radioisotope is bound directly to the surface of the substrate through non-metal atoms of the substrate and/or wherein the at least one imageable radioisotope is bound to the surface of the substrate through an inorganic bridge comprising the non-metal atoms of the substrate.
7 more elements
A method for determining an amount of therapeutic microspheres to provide to a body of a patient, the method comprising:
- delivering a population of imageable microspheres to the patient by introducing the population of imageable microspheres to a first position in a vasculature of the patient;
- allowing the population of imageable microspheres to distribute within the body of the patient;
- determining a distribution of at least a portion of the population of the imageable microspheres within the body of the patient by imaging a portion of the body of the patient using an imaging modality;
- and
- using the distribution of the imageable microspheres to calculate an amount of therapeutic microspheres to be delivered to the body of the patient;
- the imageable microspheres comprising a substrate and at least one imageable radioisotope bound to a surface of the substrate;
- wherein the substrate comprises silicon dioxide and at least one other element selected from manganese, aluminum, gallium, yttrium, boron, strontium, and titanium;
- wherein the at least one imageable radioisotope is selected from 99mTc, 201Th, 51Cr, 67Ga, 68Ga, 111In, 64Cu, 89Zr, 59Fe, 42K, 82Rb, 24Na, 45Ti, 44Sc, 51Cr, 177Lu, 18F, and/or combinations thereof;
- wherein the substrate comprises a core extending to the surface, the core comprising a first portion of metalloid or metal atoms bonded to non-metal atoms and the surface comprising a second portion of the metalloid or metal atoms bonded to the non-metal atoms;
- and
- wherein the at least one imageable radioisotope is bound directly to the substrate through the non-metal atoms of the surface of the substrate and/or wherein the at least one imageable radioisotope is bound to the substrate through an inorganic bridge comprising the non-metal atoms of the surface of the substrate.
8 more elements
A method for determining an amount of therapeutic microspheres to provide to a body of a patient, the method comprising:
- delivering a population of imageable microspheres to the patient by introducing the population of imageable microspheres to a first position in a vasculature of the patient;
- allowing the population of imageable microspheres to distribute within the body of the patient;
- determining a distribution of at least a portion of the population of the imageable microspheres within the body of the patient by imaging a portion of the body of the patient using an imaging modality;
- using the distribution of the imageable microspheres to calculate an amount of therapeutic microspheres to be delivered to the body of the patient;
- obtaining data regarding a distribution of the imageable microspheres in the patient;
- using the data to determine the amount of the therapeutic microspheres to administer to the body of the patient;
- delivering a population of the therapeutic microspheres to the patient by introducing the population of the therapeutic microspheres to a second position in the vasculature of the body of the patient;
- and
- allowing the population of the therapeutic microspheres to distribute within the body of the patient, thereby treating the patient;
- the imageable microspheres comprising a substrate and at least one imageable radioisotope bound to a surface of the substrate;
- wherein the substrate comprises silicon dioxide and at least one other element selected from manganese, aluminum, gallium, yttrium, boron, strontium, and titanium;
- wherein the at least one imageable radioisotope is selected from 99mTc, 201Th, 51Cr, 67Ga, 68Ga, 111In, 64Cu, 89Zr, 59Fe, 42K, 82Rb, 24Na, 45Ti, 44Sc, 51Cr, 177Lu, 18F, and/or combinations thereof;
- wherein the substrate comprises a core extending to a surface, the core comprising a first portion of metalloid or metal atoms bonded to non-metal atoms and the surface comprising a second portion of the metalloid or metal atoms bonded to the non-metal atoms;
- and
- wherein the at least one imageable radioisotope is bound directly to the substrate through the non-metal atoms of the surface of the substrate and/or wherein the at least one imageable radioisotope is bound to the substrate through an inorganic bridge comprising the non-metal atoms of the surface of the substrate.
12 more elements
Dependencies are inferred from the claim text.