Pharmaceutical composition comprising tetrofosmin and pharmaceutically acceptable salts thereof

A reconstituted radiopharmaceutical composition comprising:

• (i) a first component comprising an aqueous solution of 99mTc pertechnetate;
• and
• (ii) a second component comprising:
• (a) tetrofosmin disulfosalicylate in an amount between about 13.0-15.0% (w/w) of the second component;
• (b) gentisic acid in an amount between about 13.54-18.03% (w/w) of the second component;
• (c) a reducing agent in an amount between about 0.37-0.5% (w/w) of the second component;
• (d) a transchelator in an amount between about 12.0-16.0% (w/w) of the second component;
• and
• (e) a buffering agent at an amount of between about 50.0-62.0% (w/w) of the second component,
• wherein the tetrofosmin disulfosalicylate and reducing agent are present in a ratio by weight of about 30:1 to about 35:1,
• the reconstituted radiopharmaceutical composition is reconstituted from first component and second component,
• wherein the reconstituted radiopharmaceutical composition is free of ascorbate or ascorbic acid and antimicrobial preservative, and
• wherein the reconstituted radiopharmaceutical composition has a radiochemical purity of at least 90% after 12 hours of storage at a temperature of about 2-30° C.