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US 12,440,559 B2Granted
Formulation containing TLR agonist and methods of use
AssigneeAccess To Advanced Health Institute
InventorChristopher B. Fox
Life of this patent
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Abstract
Stable aqueous formulations of adjuvant comprising a TLR7/8 agonist or a TLR4 agonist with a helper lipid that are adsorbed to alum are provided. Compositions and methods of using the formulations for stimulating an immune response are also provided.
Claims10
A composition comprising:
- (a) a TLR4 agonist, wherein the TLR4 agonist is GLA;
- (b) a helper lipid;
- and
- (c) an aluminum salt,
- wherein the helper lipid is DPTAP and the aluminum salt is aluminum phosphate, or
- wherein the helper lipid is DPPC and the aluminum salt is aluminum hydroxide,
- wherein the composition is an aqueous formulation comprising a stable nanosuspension having a particle size of 400 nm or less, the TLR4 agonist is adsorbed to the aluminum salt at 25 percent or more of the aluminum salt, and the TLR4 agonist and the helper lipid are present in a molar ratio of about 1:2.
4 more elements
Dependencies are inferred from the claim text.