Multivalent recombinant avian herpes viruses and vaccines for immunizing avian species
AssigneeCeva Sante Animale
InventorsAyumi Fujisawa, Mayumi Kubomura, Sakiko Saeki, Shuji Saito
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Abstract
The present invention relates to a recombinant avian herpes virus, which comprises at least two recombinant nucleotide sequences, each recombinant nucleotide sequence encoding a distinct antigenic peptide, wherein the at least two recombinant nucleotide sequences are inserted into distinct non-coding regions of the viral genome chosen among the region located between UL44 and UL45, the region located between UL45 and UL46, the region located between US10 and SORF3, and the region located between SORF3 and US2.
Claims17
A recombinant avian herpes virus of turkeys (HVT), which comprises (i) a first recombinant nucleotide sequence encoding a glycoprotein B (gB) protein of infectious laryngotracheitis virus (ILTV) or an immunogenic fragment thereof, inserted into a non-coding region of the viral genome located between UL45 and UL46, and (ii) a second recombinant nucleotide sequence encoding an antigenic peptide, distinct from an antigenic peptide of infectious laryngotracheitis virus (ILTV), wherein said second recombinant nucleotide sequence is inserted into a non-coding region of the viral genome chosen among the region located between UL44 and UL45, the region located between US10 and SORF3, and the region located between SORF3 and US2.
Dependencies are inferred from the claim text.