Back to results
US 12,440,554 B2Granted
Vaccination using herpesvirus genomes in nucleic acid form
AssigneeThe Regents of the University of California
InventorsDennis Hartigan-O'Connor, Peter Barry, Jesse Deere, Joseph Dutra
Life of this patent
Estimating the term…
Abstract
The present invention provides compositions and methods for inducing immune responses in subjects using HV-based vectors that can be grown in single celled organisms and administered in their nucleic acid form.
Claims38
A recombinant polynucleotide comprising:
- (a) a Cytomegalovirus (CMV) genome;
- (b) a sequence comprising a bacterial artificial chromosome (BAC) origin of replication;
- and
- (c) two terminase complex recognition loci (TCRL) that flank the sequence comprising the BAC origin of replication, where each TCRL comprises two terminal repeats each comprising Pac1 and Pac2 sites;
- wherein:
- the CMV genome is separated from the sequence comprising the BAC origin of replication by the two TCRLs;
- and
- the polynucleotide is circular.
5 more elements
Dependencies are inferred from the claim text.