Compositions and methods for enhancing production, growth, spread, or oncolytic and immunotherapeutic efficacy of interferon-sensitive viruses
AssigneeOttawa Hospital Research Institute
InventorsJean-Simon Diallo, Mohammed Selman, Rozanne Arulanandam, Nicole Elise Forbes, Ramya Krishnan
Life of this patent
Estimating the term…
Abstract
Provided herein are fumaric-containing compounds, compositions comprising the same and methods for using such compounds for increasing the capacity of an interferon-sensitive virus to infect, transduce, grow or replicate in a cell or spread within one or more tissues. Also provided are methods for increasing the capacity of an interferon-sensitive virus to produce a virus-encoded transgene from a cell, by administering the compounds and compositions.
Claims20
A method for increasing the capacity of an interferon-sensitive virus to infect, transduce, grow or replicate in a cell or spread within one or more tissues, the method comprising:
- administering a compound of Formula (I), or a pharmaceutically acceptable salt or solvate thereof,
- wherein R1 and R2 are each independently OH, (C1-2)alkoxy or linear, branched or cyclic, saturated or unsaturated (C3-20)alkoxy;
- said alkoxy is optionally substituted with one or more halogen, OH, (C1-4) alkyl, nitro or cyano;
- wherein when one of R1 and R2 is OH, the other of R1 and R2 is not OH,
- to the cell before, concurrently with, or after infection of the cell with the interferon-sensitive virus.
A method for increasing the capacity of an interferon-sensitive virus to produce a virus-encoded transgene from a cell, which comprises administering a compound of Formula (I), or a pharmaceutically acceptable salt or solvate thereof,
- wherein R1 and R2 are each independently OH, (C1-2)alkoxy or linear, branched or cyclic, saturated or unsaturated (C3-20)alkoxy;
- said alkoxy is optionally substituted with one or more halogen, OH, (C1-4) alkyl, nitro or cyano;
- wherein when one of R1 and R2 is OH, the other of R1 and R2 is not OH,
- to a subject before, after, or concurrently with administering the interferon-sensitive virus to the subject.
Dependencies are inferred from the claim text.