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US 12,440,446 B2Granted
Polymeric delivery systems
AssigneeThe Secant Group, LLC
InventorsJeremy J. Harris, Scott Radzinski, Brian Ginn, Peter D. Gabriele, Benjamin Roadarmel
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AssigneeThe Secant Group, LLC
InventorsJeremy J. Harris, Scott Radzinski, Brian Ginn, Peter D. Gabriele, Benjamin Roadarmel
Estimating the term…
A polymeric delivery system delivers a biologic to cells. In some embodiments, the polymeric delivery system includes polyplexes. Each polyplex includes at least one charged polymer and at least one biologic. The at least one charged polymer includes a polyester copolymer of a polyol and a polycarboxylic acid modified with at least one charged moiety having an opposite charge from a net charge of the at least one biologic. In other embodiments, the polymeric delivery system includes self-assembled particles including a block copolymer and a biologic associated with the block copolymer. The block copolymer includes a first block of a polyester copolymer of a polyol and a polycarboxylic acid and a second block of a second monomer or a second polymer.
A polymeric delivery system comprising polyplexes comprising at least one charged polymer and at least one biologic, wherein the at least one charged polymer comprises a polyester copolymer of alternating monomers of a polyol monomer and a polycarboxylic acid monomer, wherein the polyol monomer comprises glycerol and wherein the polyester copolymer of alternating monomers of a polyol monomer and a polycarboxylic acid monomer has been modified by derivatization of at least a portion of free alcohols of the glycerol to incorporate at least one charged moiety having an opposite charge from a net charge of the at least one biologic, wherein the at least one charged moiety is selected from the group consisting of glutamine, lysine, arginine, sulfate, phosphate, sulfonate, sulfite, carboxy salt, ammonium, choline, phosphocholine, primary amine, secondary amine, tertiary amine, quaternary amine, and carboxylate.
A process of forming a polymeric delivery system comprising polyplexes, the process comprising combining charged polymers and biologics in a solvent to associate the charged polymers and the biologics as the polyplexes, the polyplexes comprising at least one of the charged polymers and at least one of the biologics, wherein the polyol monomer comprises glycerol and wherein each of the charged polymers comprises a polyester copolymer of alternating monomers of a polyol monomer and a polycarboxylic acid monomer, wherein the polyester copolymer of alternating monomers of a polyol monomer and a polycarboxylic acid monomer has been modified by derivatization of at least a portion of free alcohols of the glycerol to incorporate at least one charged moiety having an opposite charge from a net charge of the biologics, wherein the at least one charged moiety is selected from the group consisting of glutamine, lysine, arginine, sulfate, phosphate, sulfonate, sulfite, carboxy salt, ammonium, choline, phosphocholine, primary amine, secondary amine, tertiary amine, quaternary amine, and carboxylate.
A process of delivering a biologic to cells, the process comprising administering polyplexes of the biologic associated with a charged polymer, the charged polymer comprising a polyester copolymer of alternating monomers of a polyol monomer and a polycarboxylic acid monomer, wherein the polyol monomer comprises glycerol and wherein the polyester copolymer of alternating monomers of a polyol monomer and a polycarboxylic acid monomer has been modified by derivatization of at least a portion of free alcohols of the glycerol to incorporate at least one charged moiety having an opposite charge from a net charge of the biologic, wherein the at least one charged moiety is selected from the group consisting of glutamine, lysine, arginine, sulfate, phosphate, sulfonate, sulfite, carboxy salt, ammonium, choline, phosphocholine, primary amine, secondary amine, tertiary amine, quaternary amine, and carboxylate.
Dependencies are inferred from the claim text.