Back to results
US 12,440,435 B2Granted
Solubilization of poorly soluble cooling substances
AssigneeSymrise AG
InventorsJenny Weissbrodt, Michael Backes, Rita Lages, Olga Pauli
Life of this patent
Estimating the term…
Abstract
The present invention relates to a cooling composition for producing cooling particles comprising a solvent component and dissolved therein (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)-cyclohexane-carboxamide. The present invention further relates to cooling particles comprising a cooling composition according to the invention, oral preparations comprising cooling particles, new uses of cooling particles, a process for the production of cooling particles as well as the use of a solvent component for dissolving cooling agents.
Claims20
Cooling particles comprising:
- (I) 5 to 40% by weight, based on a total weight of the cooling particles, of a cooling composition, the cooling composition comprising:
- (A) 80 to 99% by weight, based on a total weight of the cooling composition, of a solvent component consisting of:
- (i) 2-hydroxypropyl (2-isopropyl-5-methyl-cyclohexyl) carbonate and/or (2-isopropyl-5-methyl-cyclohexyl) 2-hydroxypropanoate;
- (ii) optionally, N-ethyl-2-isopropyl-5-methyl-cyclohexanecarboxamide;
- and
- (iv) optionally, 0.5 to 8% by weight, based on a total weight of the solvent component, of medium-chain triglycerides;
- and
- (B) 0.5 to 12% by weight, based on a total weight of the cooling composition, of a cooling agent that is (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)-cyclohexane-carboxamide,
- wherein the cooling agent (B) is dissolved in the solvent component (A) at room temperature;
- and
- (II) a matrix material that encapsulates the cooling composition (I),
- wherein the particles have an average particle diameter D50 of 10 to 2000 μm as determined by laser light diffraction according to ISO ISO13320:2009-10.
9 more elements
Cooling particles comprising:
- (I) 10 to 30% by weight, based on a total weight of the cooling particles, of a cooling composition, the cooling composition comprising:
- (A) 80 to 99% by weight, based on a total weight of the cooling composition, of a solvent component comprising:
- (i) 2 to 20% by weight, based on a total weight of the solvent component, of 2-hydroxypropyl (2-isopropyl-5-methyl-cyclohexyl) carbonate;
- (ii) 55 to 75% by weight, based on the total weight of the solvent component, of (2-isopropyl-5-methyl-cyclohexyl) 2-hydroxypropanoate;
- and
- (iii) 15 to 35% by weight, based on the total weight of the solvent component, of N-ethyl-2-isopropyl-5-methyl-cyclohexanecarboxamide;
- and
- (B) 1 to 10% by weight, based on the total weight of the cooling composition, of a cooling agent that is (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)-cyclohexane-carboxamide;
- and
- (II) a matrix material that encapsulates the cooling composition (I),
- wherein the cooling agent (B) is dissolved in the solvent component (A) at room temperature, and
- the particles have an average particle diameter D50 of 10 to 2000 μm as determined by laser light diffraction according to ISO ISO13320:2009-10.
9 more elements
Cooling particles comprising:
- (I) 10 to 30% by weight, based on a total weight of the cooling particles, of a cooling composition, the cooling composition comprising:
- (A) 80 to 99% by weight, based on a total weight of the cooling composition, of a solvent component comprising:
- (i) 4 to 15% by weight, based on a total weight of the solvent component, of 2-hydroxypropyl [(1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl] carbonate;
- (ii) 60 to 70% by weight, based on the total weight of the solvent component, of [(1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl] (2S)-2-hydroxypropanoate;
- (iii) 20 to 30% by weight, based on the total weight of the solvent component, of (1R,2S,5R)-N-ethyl-2-isopropyl-5-methyl-cyclohexanecarboxamide;
- and
- (iv) optionally, 0.5 to 8% by weight, based on the total weight of the solvent component, of medium-chain triglycerides;
- (B) 1 to 10% by weight, based on a total weight of the cooling composition, of a cooling agent that is (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)-cyclohexane-carboxamide;
- and
- (II) a matrix material that encapsulates the cooling composition (I),
- wherein the cooling agent (B) is dissolved in the solvent component (A) at room temperature, and
- the particles have an average particle diameter D50 of 10 to 2000 μm as determined by laser light diffraction according to ISO ISO13320:2009-10.
9 more elements
Dependencies are inferred from the claim text.