Anti-pathogenic activity of a bifunctional peptidoglycan/chitin hydrolase
AssigneeUniversiteit Antwerpen
InventorsCamille Allonsius, Sarah Lebeer
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Abstract
The present invention generally relates to the use of a bifunctional peptidoglycan/chitin hydrolase to reduce and/or prevent hyphae formation in a pathogen, and/or to reduce or prevent biofilm formation. The present invention further relates to a bifunctional peptidoglycan/chitin hydrolase for use in the treatment and/or prevention of pathogenic infections, in particular yeast or bacterial infections. In another aspect, the present invention provides the use of a bifunctional peptidoglycan/chitin hydrolase as a anti-pathogenic agent in non-medical applications; in particular in the personal hygiene industry, food industry, cleaning industry, pharma industry, or biocontrol and crop protection industry.
Claims16
A method of reducing and/or preventing hyphae formation in a hyphae-forming pathogen, the method comprising contacting the pathogen with a composition consisting of (i) an effective amount of a bifunctional peptidoglycan/chitin hydrolase purified from a supernatant of a Lactobacilliae strain, and (ii) lactic acid, wherein the bifunctional peptidoglycan/chitin hydrolase is major secreted protein 1 (Msp1), and wherein the pathogen contacts the Msp1 and lactic acid.
A method of treating and/or preventing a hyphae-forming pathogenic infection in a subject in need thereof, the method comprising treating the subject with a composition consisting of (i) an effective amount of a bifunctional peptidoglycan/chitin hydrolase purified from a supernatant of a Lactobacilliae strain, and (ii) lactic acid, wherein the bifunctional peptidoglycan/chitin hydrolase is major secreted protein (Msp1).
A method of reducing and/or preventing hyphae formation in a hyphae-forming pathogen, the method comprising contacting the pathogen with a composition consisting of an effective amount of major secreted protein 1 (Msp1) and lactic acid, wherein the Msp1 is purified from a supernatant of a Lactobacilliae strain.
A method of reducing and/or preventing hyphae formation in a hyphae- forming pathogen, the method comprising contacting the pathogen with a composition consisting of (i) an effective amount of a bifunctional peptidoglycan/chitin hydrolase purified from a supernatant of a Lactobacillaceae strain, (ii) lactic acid and a Lactobacillaceae strain selected from the group consisting of:
- Lacticaseibacillus rhamnosus, Lacticaseibacillus casei, Lacticaseibacillus paracasei, and Limosilactobacillus fermentum, wherein the bifunctional peptidoglycan/chitin hydrolase is major secreted protein 1 (Msp1), and wherein the pathogen contacts the Msp1 and lactic acid.
Dependencies are inferred from the claim text.