Infection detection and differentiation systems and methods

An automated system for evaluating an infection status association with a blood sample obtained from an individual, the system comprising:

• a transducer for obtaining current data for the blood sample as the sample passes through an aperture;
• a processor;
• and
• a storage medium comprising a computer application that, when executed by the processor, is configure to cause the system to:
• use a parameter calculated using a monocyte volume measure based on the current data and a cell count or neutrophil concentration of white blood cells associated with the blood sample to evaluate the infection status associated with the blood sample, and
• output from the processor information relating to the evaluated infection status of the blood sample.

An automated system for evaluating an infection status associated with a blood sample obtained from an individual, the system comprising:

• a first module configured to determine a cell count or neutrophil concentration of white blood cells of the blood sample;
• a second module comprising:
• an electrode assembly configured to measure direct current (DC) impedance of cells of the blood sample passing individually through a cell interrogation zone;
• and
• a data processing module in connectivity with the first module and the second module, the data processing module comprising a processor and a tangible non-transitory computer readable medium, the tangible non-transitory computer readable medium programmed with a computer application that, when executed by the processor, causes the processor to calculate a parameter using a standard deviation of monocyte volume associated with the blood sample and the cell count or neutrophil concentration of white blood cells, and to evaluate the infection status associated with the blood sample based on the parameter,
• wherein the standard deviation of monocyte volume is determined using the DC impedance measurement of the cells of the biological sample.