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US 12,436,150 B2Granted
CD127 expression inversely correlates with FoxP3 and suppressive function of CD4+ Tregs
AssigneeThe Regents of the University of California
InventorsJeffrey A. Bluestone, Weihong Liu, Amy Putnam
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Abstract
The invention provides methods of isolating CD 127lo/− immunosuppressive regulatory T cells which can be greatly enriched for FoxP3, methods of expanding the isolated cells, pharmaceutical compositions of such cells, and methods of their use in the treatment of autoimmune and other immune system mediated disorders.
Claims17
A method of making an isolated population of immunosuppressive regulatory T-cells, the method comprising:
- screening a sample comprising human T cells for the levels of cell surface expression of a CD4 marker and a CD127 marker to detect CD4+CD127lo/− cells, wherein the CD4+CD127lo/− cells have reduced or no levels of cell surface-expressed CD127 compared to other cells in the sample expressing greater amounts of CD127;
- and
- isolating the CD4+CD127lo/− cells from the sample to provide the isolated population of immunosuppressive regulatory T-cells.
Dependencies are inferred from the claim text.