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US 12,435,142 B2Granted
Anti-CTLA4 antibodies and methods of use thereof
AssigneeXilio Development, Inc.
InventorMargaret Karow
Life of this patent
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Abstract
The invention provides anti-CTLA4 binding proteins (e.g., antibodies, bispecific antibodies, and chimeric receptors) and their use in treating and preventing cancer, as well as compositions and kits comprising the anti-CTLA4 binding proteins.
Claims16
An anti-CTLA4 antibody comprising a light chain variable (VL) domain and a heavy chain variable (VH) domain, wherein:
- the VL domain comprises (i) a CDR-L1 comprising the amino acid sequence of SEQ ID NO:
- 19, (ii) a CDR-L2 comprising the amino acid sequence of SEQ ID NO:
- 20, and (iii) a CDR-L3 comprising the amino acid sequence of SEQ ID NO:
- 21;
- and the VH domain comprises (1) a CDR-H1 comprising the amino acid sequence of SEQ ID NO:
- 22, (ii) a CDR-H2 comprising the amino acid sequence of SEQ ID NO:
- 23, and (iii) a CDR-H3 comprising the amino acid sequence of SEQ ID NO:
- 24;
- and
- wherein the antibody comprises a heavy chain constant region (CH) comprising substitutions S239D and I332E, wherein the amino acid residues are numbered according to EU index as in Kabat.
7 more elements
A bispecific antibody comprising:
- 1) a light chain and a heavy chain of a first pair that specifically binds to CTLA4;
- 2) a light chain and a heavy chain of a second pair that specifically binds to an antigen;
- wherein the light chain of the first pair comprises a VL domain, and the heavy chain of the first pair comprises a VH domain and wherein:
- the VL domain comprises (1) a CDR-L1 comprising the amino acid sequence of SEQ ID NO:
- 19, (ii) a CDR-L2 comprising the amino acid sequence of SEQ ID NO:
- 20, and (iii) a CDR-L3 comprising the amino acid sequence of SEQ ID NO:
- 21;
- and the VH domain comprises (i) a CDR-H1 comprising the amino acid sequence of SEQ ID NO:
- 22, (ii) a CDR-H2 comprising the amino acid sequence of SEQ ID NO:
- 23, and (iii) a CDR-H3 comprising the amino acid sequence of SEQ ID NO:
- 24
- wherein the heavy chain of the first pair comprises a heavy chain constant region (CH) comprising substitutions S239D and I332E, wherein the amino acid residues are numbered according to EU index as in Kabat.
9 more elements
Dependencies are inferred from the claim text.