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US 12,435,112 B2Granted
Adenovirus comprising a modified adenovirus hexon protein
AssigneeUniversitäT Ulm
InventorsStefan Kochanek, Lea Krutzke, Robin Nilson, Olivia Lübbers
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AssigneeUniversitäT Ulm
InventorsStefan Kochanek, Lea Krutzke, Robin Nilson, Olivia Lübbers
Estimating the term…
The invention discloses a human adenovirus species C having a capsid which comprises a modified adenovirus hexon protein, wherein the modified adenovirus hexon protein has a modified HVR1 region, wherein the modified HVR1 region has the sequence DEAATALEINLKKKKQAEQQ (SEQ ID NO.: 1). The invention further discloses the adenovirus of the disclosure for use in treating or preventing a human disease. The invention further discloses a nucleic acid encoding the modified adenovirus hexon protein. The invention further discloses the use of an adenovirus according to the disclosure for transducing mesenchymal stromal cells (MSCs) or tumor cells. The invention further discloses an in vitro method for transducing MSCs and a transduced MSC obtainable by the method. The invention further discloses the transduced MSC of the disclosure for use in treating a disease.
A human adenovirus species C comprising a capsid which comprises a modified adenovirus hexon protein, wherein the modified adenovirus hexon protein has a modified HVR1 region, wherein the modified HVR1 region comprises the sequence DEAATALEINLKKKKQAEQQ (SEQ ID NO.:
A nucleic acid encoding a modified adenovirus hexon protein of a human adenovirus species C, wherein the modified adenovirus hexon protein comprises a modified HVR1 region, wherein the modified HVR1 region comprises the sequence of SEQ ID NO.:
Dependencies are inferred from the claim text.