Adenosomes
AssigneeErasmus University Medical Center Rotterdam
InventorJeroen De Vrij
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Abstract
The invention relates to a recombinant adenovirus nucleic acid wherein the gene encoding protein V and/or the gene encoding protein VII is placed under control of a heterologous promoter, to a recombinant adenovirus nucleic acid wherein the adenoviral nucleotide sequence is mutated in such a way that it is no longer capable of producing one or more of the coat proteins, to cellular vesicles filled with such adenoviral material, cells provided with such adenoviral material and to methods and use thereof.
Claims14
Cellular vesicle comprising a recombinant adenoviral nucleic acid, wherein the recombinant adenoviral nucleic acid comprises a mutation in the early genes, wherein the gene encoding protein V and/or the gene encoding protein VII is placed under control of a heterologous promoter.
Cellular vesicle comprising a recombinant adenoviral nucleic acid wherein the gene encoding protein V and/or the gene encoding protein VII is placed under control of a heterologous promoter.
Cellular vesicle comprising:
- i. a nucleic acid molecule comprising a recombinant adenoviral nucleic acid wherein the gene encoding protein V and/or the gene encoding protein VII is placed under control of a heterologous promoter and wherein said nucleic acid does not comprise adenoviral nucleic acid other than the genes encoding protein V and/or protein VII, and a recombinant adenoviral nucleic acid comprising a mutation in the early genes, and optionally a heterologous gene, or
- ii. a recombinant adenoviral nucleic acid wherein the gene encoding protein V and/or the gene encoding protein VII is placed under control of a heterologous promoter, wherein protein V and/or protein VII is fused with a heterologous molecule, and wherein said nucleic acid does not comprise adenoviral nucleic acid other than the genes encoding protein V and/or protein VII, or
- iii. adenoviral protein V and/or protein VII, wherein protein V and/or protein VII is fused with a heterologous molecule, and a recombinant adenoviral nucleic acid comprising a mutation in the early genes, wherein the recombinant adenoviral nucleic acid is an adenoviral nucleic acid of a conditionally replicating adenovirus and/or a replication-deficient adenovirus vector, or
- iv. adenoviral protein V and/or protein VII wherein protein V and/or protein VII is fused with a heterologous molecule.
Dependencies are inferred from the claim text.