Compositions and methods for dissolving protein aggregates

A host cell comprising a polynucleotide encoding a polypeptide, wherein the polypeptide comprises a hydrophilic segment and a hydrophobic segment, wherein the hydrophilic segment comprises a sequence selected from the group consisting of:

• (SEQ ID NO:
• 15)
• TEPQEESEEEVEEPEER,
• (SEQ ID NO:
• 16)
• TDPQDDSDDDVDDPDDR,
• (SEQ ID NO:
• 17)
• TKPQKKSKKKVKKPKKR,
• (SEQ ID NO:
• 18)
• TRPQRRSRRRVRRPRRR,
• (SEQ ID NO:
• 19)
• ELDEESEDEVEEEQEDR,
• (SEQ ID NO:
• 20)
• KEEVDEDRDVDE,
• and
• (SEQ ID NO:
• 21)
• EKSEQDLE,
• or a sequence having at least 90% identity thereto,
• wherein the hydrophobic segment comprises a sequence selected from the group consisting of:
• (SEQ ID NO:
• 22)
• TFYDQTVSNDL,
• (SEQ ID NO:
• 23)
• ANSAYYDAHPVTNGI,
• (SEQ ID NO:
• 24)
• PPQTAAREATSIPGFPAEGAIPLPV,
• and
• (SEQ ID NO:
• 25)
• EGEVAEEPNSRP,
• or a sequence having at least 90% identity thereto,
• wherein the hydrophilic segment is at the N-terminus and the hydrophobic segment is at the C-terminus,
• wherein the polypeptide has a length of 20-60 amino acid residues, and
• wherein the polypeptide is capable of dissolving a protein aggregate.