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US 12,435,094 B1Granted
Methods of preparing isomers, analogs, and synthetic derivatives from akuamma seeds
OwnerHaywood Max Mitchell, Cecil Page +1inventors
InventorsHaywood Max Mitchell, Cecil Page, Joseph William Merino
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Abstract
Methods are provided for the extraction, isolation, and synthesis of akuammine and other naturally occurring alkaloids from the seeds of the plant Picralima nitida (Akuamma), and their conversion to a variety of isomers, analogs, and synthetic derivatives.
Claims15
A method for producing a synthetic compound from alkaloids obtained from akuamma, comprising:
- dissolving a predetermined amount of powdered akuamma in a solvent under an argon atmosphere to form a first solution;
- subjecting the first solution to an extraction process to recover a first extract possessing the alkaloids from the akuamma;
- concentrating the first extract to obtain a second extract;
- purifying the second extract using liquid-liquid extraction to obtain a third extract;
- isolating the alkaloids from the third extract;
- collecting the alkaloids;
- and
- converting the alkaloids to the synthetic compound by a reaction selected from deprotonation, oxidation, alkylation, acylation, halogenation, or ring modification reactions.
5 more elements
Dependencies are inferred from the claim text.