Salicyl-adenosinemonosulfamate analogs and uses thereof

A compound of Formula (I):

• or a pharmaceutically acceptable salt, stereoisomer, or tautomer thereof, wherein:
• R1 is optionally substituted alkyl, optionally substituted heteroalkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted acyl;
• each or R2 and R3 is hydrogen, halogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted acyl, —NO2, —CN, —ORe, —N(Re)2, —N3, —SO2H, —SO3H;
• —SH, —SRe, —SSRe, —OC(═O)Re, —OCO2Re, —OC(═O)N(Re)2, —C(═O)N(Re)2, —NC(═O)N(Re)2, —OC(═O)O(Re)2, —SO2Re, —SO2ORe, —OSO2Re, —S(═O)Re, or —OS(═O)Re;
• each of R9, R10, R11 and R12 is hydrogen, halogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted acyl, —NO2, —CN, —OR4, —OR5, —ORe, —N(Re)2, —N3, —SO2H, —SO3H;
• —SH, —SRe, —SSRe, —OC(═O)Re, —OCO2Re, —OC(═O)N(Re)2, —OC(═O)N(Re)2, —C(═O)N(Re)2, —NC(═O)N(Re)2, —OC(═O)O(Re)2, —SO2Re, —SO2ORe, —OSO2Re, —S(═O)Re, —OS(═O)Re, or two occurrences of any R9, R10, R11 and R12 are joined to form an optionally substituted carbocyclic ring or an optionally substituted heterocyclic ring;
• each of R4 and R5 is independently hydrogen, optionally substituted C1-6 alkyl, optionally substituted acyl, or an oxygen protecting group, or R4 and R5 are joined to form an optionally substituted heterocyclic ring;
• X1 is a bond, —O—, —(C(Rd)2)q—, or —NRe—;
• each occurrence of Rd is independently hydrogen, halogen, optionally substituted C1-6 alkyl, —ORe, or —N(Re)2;
• each occurrence of Re is independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted acyl, an oxygen protecting group when attached to an oxygen atom, a nitrogen protecting group when attached to a nitrogen atom, or two Re are joined to form an optionally substituted carbocyclic, an optionally substituted aryl, an optionally substituted heterocyclic or optionally substituted heteroaryl ring;
• q is 1, 2, or 3;
• each occurrence of R7 is independently halogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted acyl, —NO2, —CN, —ORe, or —N(Re)2, or two R7 are joined to form an optionally substituted aryl or optionally substituted heteroaryl ring;
• and
• n is 0, 1, 2, 3, 4, or 5.