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US 12,435,034 B2Granted
Process of preparing 3-fluoro-5(((1R,2AR)-3,3,4,4-tetrafluoro-1,2A-dihydroxy-2,2A,3,4-tetrahydro-1H-cyclopenta[cd]inden-7-yl)-oxy)benzonitrile
AssigneeNikang Therapeutics, Inc.
InventorsJiping Fu, Yan Lou, Yigang He, Yuetao Shi, Peng Zhou, Xingxing Li
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Abstract
Disclosed herein are processes for preparing certain intermediates useful in the synthesis of 3-fluoro-5-(((1S,2aR)-1,3,3,4,4-pentafluoro-2a-hydroxy-2,2a,3,4-tetrahydro-1H-cyclopenta[cd]inden-7-yl)oxy)benzonitrile or a pharmaceutically acceptable salt thereof.
Claims20
A process of preparing compound (11):
- comprising reducing the keto moiety of compound (10):
- with a suitable reducing agent in a suitable organic solvent and optionally in the presence of an organic acid, wherein the reducing agent is sodium borohydride, lithium borohydride, sodium acetoxy borohydride, or sodium cyanoborohydride;
- and
- (a) further comprising preparing compound (10):
- by reacting compound (9):
- with 3-fluoro-5-hydroxybenzonitrile in the presence of a base in a suitable organic solvent.
3 more elements
Dependencies are inferred from the claim text.