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US 12,435,032 B2Granted
L-γ-methyleneglutamine compounds and methods of use
AssigneeThe University of Mississippi
InventorsHoang Van Le, Md. Imran Hossain
Life of this patent
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Abstract
Disclosed are substantially pure L-y-methyleneglutamine, L-y-methyleneglutamic acid, and/or amide derivatives, and methods of use thereof. In particular, the presently disclosed subject matter relates to L-y-methyleneglutamine, L-y-methyleneglutamic acid, and/or amide derivatives thereof, and methods of treating cancer. The method comprises administering one or more substantially pure L-y-methyleneglutamine, L-y-methyleneglutamic acid, and/or amide derivatives to a subject in need thereof.
Claims15
A compound having a structure according to Formula I:
- wherein R1 is NHR4;
- R2 is H or an amine protecting group;
- R3 is OH, or substituted or unsubstituted lower alkoxy;
- and
- R4 is an alkyl group substituted with an aryl group or a heteroaryl group, substituted or unsubstituted aryl, substituted or unsubstituted hetaryl.
2 more elements
Dependencies are inferred from the claim text.