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US 12,435,028 B2Granted
Processes for the preparation of (S)-tert-butyl 4,5-diamino-5-oxopentanoate
AssigneeCelgene Corporation
InventorsJohn F. Traverse, Michael J. Zacuto, Weihong Zhang, Kirsten Faye Johnson, Maryll E. Geherty, Christopher Marton
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Abstract
Provided are processes for the preparation of (S)-tert-butyl 4,5-diamino-5-oxopentanoate, or a salt, solvate, hydrate, enantiomer, mixture of enantiomers, or isotopologue thereof. Also provided are solid forms of various intermediates and products obtained from the processes.
Claims6
A process for the preparation of O-t-Bu-DIC isourea of the structure:
- comprising reacting diisopropylcarbodiimide (DIC) with t-butanol and a Cu(I) salt in the presence of oxygen, wherein the oxygen is present in an amount of from about 1% to about 10% of the atmosphere.
Dependencies are inferred from the claim text.