Continuous processing system and methods for internal and external modifications to nanoparticles

A system for internal and external modification of pre-formed nanoparticles in a continuous process, the system comprising:

• a first inlet;
• a second inlet;
• a first pump in fluid communication with the first inlet;
• a second pump in fluid communication with the second inlet;
• a first flow meter in fluid communication with the first pump;
• a second flow meter in fluid communication with the second pump;
• a mixing chamber in fluid communication with the first flow meter and the second flow meter;
• a first heat exchanger in fluid communication with the mixing chamber;
• a first analyzer positioned downstream from the first heat exchanger, wherein the first analyzer is configured to measure a first attribute of a plurality of modified pre-formed nanoparticles;
• a second analyzer positioned downstream from the first analyzer, wherein the second analyzer is configured to measure a second attribute of the plurality of modified pre-formed nanoparticles that is different than the first attribute;
• and
• a controller configured to:
• determine a difference between one or more desired attributes of the plurality of modified nanoparticles and one or more determined attributes of the plurality of modified nanoparticles;
• and
• in response to the determined difference, adjust one or more parameters of the system.