Back to results
US 12,433,946 B2Granted
Immunomodulatory fusion protein-metal hydroxide complexes and methods thereof
AssigneeMassachusetts Institute of Technology
InventorsDarrell J. Irvine, Karl Dane Wittrup, Tyson Moyer, Yash Agarwal
Life of this patent
Estimating the term…
Abstract
The present disclosure provides immunomodulatory fusion proteins-metal hydroxide complexes comprising an immunomodulatory domain adsorbed to a metal hydroxide via ligand exchange. The disclosure also features compositions and methods of using the same, for example, to treat cancer.
Claims24
An immunomodulatory fusion protein comprising:
- (a) an immunomodulatory domain, wherein the immunomodulatory domain is or comprises interleukin-12 (IL-12);
- and
- (b) a metal hydroxide-binding peptide having an amino acid sequence motif comprising at least one phosphorylated amino acid, which sequence motif is or comprises:
- S-X-E, S-X-pS, or S-X-Q-X-X-D-E (SEQ ID NO:
- 206), wherein X is any amino acid.
2 more elements
An immunomodulatory fusion protein-metal hydroxide complex comprising:
- (a) an immunomodulatory fusion protein comprising:
- (i) an immunomodulatory domain, wherein the immunomodulatory domain is or comprises interleukin-12 (IL-12), and
- (ii) a metal hydroxide-binding peptide having an amino acid sequence motif comprising at least one phosphorylated amino acid, which sequence motif is or comprises:
- S-X-E, S-X-pS, or S-X-Q-X-X-D-E (SEO ID NO:
- 206), wherein X is any amino acid, and
- (b) a metal hydroxide,
- wherein the immunomodulatory fusion protein is adsorbed via ligand exchange to the metal hydroxide via the at least one phosphorylated amino acid of the metal hydroxide-binding peptide, thereby forming the immunomodulatory fusion protein-metal hydroxide complex.
4 more elements
Dependencies are inferred from the claim text.