US 12,433,944 B2 · Vaccine composition

Abstract

The present invention relates to vaccine compositions, most notably vaccine compositions wherein the antigenic component is large, for example over 50 kDa, or multimeric, i.e. comprised of subunits. Such antigenic components are of particular interest, because they may represent antigenic components from pathogens that currently it is not possible to vaccinate against. The invention relates to a composition comprising a particle displaying an antigenic component, wherein said composition comprises an antigenic component comprising a first peptide tag, and a moiety comprising a second peptide tag, wherein the antigenic component and the moiety are linked via an isopeptide bond between said first and second peptide tags, and wherein the antigenic component is over 50 kDa, or alternatively is multimeric.

Claims15

Dependent claims

A composition comprising a virus-like particle displaying an antigenic component, wherein said composition comprises:

i) an antigenic component comprising a first peptide tag, and
ii) a moiety comprising a second peptide tag,
wherein the antigenic component and the moiety are linked via an isopeptide bond between said first and second peptide tags, wherein the antigenic component is over 50 kDa and is a multimer;
wherein the moiety is a surface antigen of the hepatitis B virus (HBsAg) and multimerises to form the virus-like particle;
wherein the first peptide tag is a SpyTag having the amino acid sequence set out in SEQ ID NO:
30;
and
wherein the second peptide tag is a SpyCatcher having the amino acid sequence set out in SEQ ID NO:
38.

6 more elements

Dependencies are inferred from the claim text.

Vaccine composition

Life of this patent

Vaccine composition

Life of this patent

Abstract

Claims15