Ang (1-7) derivative oligopeptides for the treatment of pain
AssigneeArizona Board of Regents on Behalf of the University of Arizona
InventorsMeredith Hay, John Konhilas, Robin L. Polt, Todd Vanderah, Brittany Forte, Tally Milnes, Evan Jones, Lajos Szabo
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Abstract
The present invention provides oligopeptides, in particular, Ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment, oligopeptides of the invention have higher blood-brain barrier penetration and/or in vivo half-life compared to the native Ang-(1-7), thereby allowing oligopeptides of the invention to be used in a wide variety of clinical applications including in treatment of cognitive dysfunction and pain.
Claims1
A method for treating a painful condition in a subject comprising administering a therapeutically effective amount of an oligopeptide having the formula:
- A1-A2-A3-A4-A5-A6-A7-A8 (SEQ ID NO:10) wherein
- A1 is aspartic acid;
- A2 is arginine;
- A3 is valine;
- A4 is tyrosine;
- A5 is isoleucine;
- A6 is histidine;
- A7 is serine;
- and
- A8 is absent,
- wherein the painful condition is selected from the group consisting of acute pain, trauma-induced pain, dental pain, and osteoarthritis,
- wherein the oligopeptide is glycosylated with a monosaccharide or disaccharide.
Dependencies are inferred from the claim text.