Compositions and methods of treatment for neurological disorders comprising depression

A method of treating a neurological disease or delaying of said neurological disease, wherein said neurological disease is depression or a subtype thereof in a subject in need thereof, said method comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula II:

• wherein:
• RII′ is —H;
• BII is optionally substituted cyclopentyl;
• XII′ is —NR*—, or optionally substituted piperidinyl, piperazinyl, or pyrrolidinyl;
• XII is an optionally substituted C1-C10 alkylenyl wherein optionally one or more carbon atoms are each independently replaced by —O—, or —NR*—;
• YII is optionally substituted pyridyl, optionally substituted thiophenyl, optionally substituted furanyl, optionally substituted pyrazolyl, or optionally substituted phenyl;
• and
• each R* is independently —H or optionally substituted C1-C6 alkyl;
• and a pharmaceutically acceptable carrier, diluent or excipient thereof.