Malleable controlled release local anesthetic with hemostatic composition
AssigneeRilento Pharma, LLC
InventorKhashayar Kevin Neshat
Life of this patent
Estimating the term…
Abstract
A malleable sustained release formulation is created utilizing a local anesthetic wherein the composition is made sustained release by incorporating it into a bovine or porcine hemostatic agent. The composition is malleable enough to fit into a cavity such as a dental cavity and form the shape of the cavity. In addition to providing sustained release of the anesthetic, the composition also provides quicker reduction in bleeding.
Claims7
A malleable sustained release formulation designed for packing and sticking in a dental extraction cavity, a surgical cavity or a wound cavity of a patient, the formulation comprising:
- a homogenous dry blend including
- a. a local anesthetic formulated into sustained release microparticles, of a size between 0.1 and 100 microns, the microparticles encapsulating the local anesthetic for forming a primary sustained release vehicle for the local anesthetic by diffusion from the microparticles;
- b. an absorbable a gelatin powder, wherein the gelatin is selected from the group consisting of a bovine skin hemostatic composition agent and porcine skin hemostatic agent;
- and
- c. an aqueous solution,
- wherein the gelatin powder and the aqueous solution form a gelled matrix with the local anesthetic sustained release microparticles incorporated into and suspended within the gelled matrix such that the gelled matrix comprises a secondary sustained release vehicle for the local anesthetic microparticles by diffusion through the matrix, and
- wherein the gelled matrix is a malleable putty prior to its insertion into the cavity of a patient such that a bolus of the malleable formulation can be mixed by hand under low shear ambient conditions for molding a bolus manually sized and shaped to fit the cavity and be retained therein.
Dependencies are inferred from the claim text.