Treatment of Acanthamoeba or Balamuthia trophozoites and/or cysts
AssigneeGeorgia State University Research Foundation, Inc.
InventorsDavid W. Boykin, Dennis E. Kyle, Christopher A. Rice, Abdelbasset A. Farahat
Life of this patent
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Abstract
Compounds, compositions, and methods for the treatment of infections caused by Acanthamoeba or Balamuthia mandrillaris trophozoites and/or cysts and for the disinfection of solids and/or liquids, such as medical and personal care items, for example contact lenses, that may harbor Acanthamoeba trophozoites and/or cysts are provided.
Claims28
A compound of Formula 2 or Formula 3:
- or a pharmaceutically acceptable salt thereof;
- wherein:
- R3 and R4 are independently selected from hydrogen, halo, C1-C4alkoxy, and C1-C4haloalkyl, wherein at least one of R3 and R4 is not hydrogen;
- R5 is selected from halo, C1-C4alkoxy, and C1-C4haloalkyl;
- R6 and R7 are independently selected from hydrogen, halo, C1-C4alkoxy, and C1-C4haloalkyl, wherein at least one of R6 and R7 is not hydrogen;
- R8 is selected from halo, C1-C4alkoxy, and C1-C4haloalkyl;
- R9 and R10 are independently selected from hydrogen, halo, C1-C4alkoxy, and C1-C4haloalkyl, wherein at least one of R9 and R10 is not hydrogen;
- RX and RY are independently selected at each occurrence from halo, C1-4alkoxy, and C1-C4haloalkyl;
- o and p are independently selected 0, 1, 2, and 3;
- and
- RA and RB are independently C1-C6alkyl.
A compound selected from the group consisting of:
- or a pharmaceutically acceptable salt thereof.
A method for treating an infection caused by Balamuthia mandrillaris or a Acanthamoeba species in a host comprising administering an effective amount of a compound from the group consisting of:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.