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US 12,433,852 B2Granted
Self-adhesive patches made of fibres for the controlled release of bioactives
AssigneesBionanopharma S.L., Consejo Superior De Investigaciones Cientificas (Csic)
InventorsJose Maria Lagaron Cabello, Cristina Prieto López, María de Las Mercedes Pardo Figuérez, Jorge Teno Díaz
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Abstract
The present invention falls within the area of polymeric materials based on ultrafine fibres for use in the pharmaceutical, nutraceutical and cosmetic sector, relating to the method of producing self-adhesive patches and the use thereof as a platform for the controlled release of bioactives by electrohydrodynamic and/or aerohydrodynamic processing techniques.
Claims22
A self-adhesive patch as a platform for controlled release of bioactives comprising at least:
- i) a first block A which is in contact with the corporal mucosa or skin to which it adheres characterised in that it is formed by at least one layer made of hydrophilic polymers, and in that it has a surface density of at least 0.2 g/m2, wherein the hydrophilic polymers of the block A form an emulsified mixture of polyethylene oxide and polyvinylpyrrolidone;
- ii) a second block B deposited on the block A obtained by electrohydrodynamic processing, aerodynamic processing or combination of the two, containing the encapsulated bioactive(s), characterised in that it is formed by at least one layer of fibres made of at least one hydrophobic polymer, and in that it has a surface density of at least 0.2 g/m2;
- iii) a third block C deposited on the block B, wherein the block C is formed by at least one layer, characterized in that it is obtained by electrohydrodynamic processing, aerodynamic processing or combination of the two and made up of one or more hydrophobic polymers which are selected from poly-ε-caprolactone, poly-ε-caprolactone copolymers, polylactic acid and the copolymers thereof, and polyhydroxyalkanoates, or any of the mixtures thereof, and in that it has a surface density of at least 0.2 g/m2.
Dependencies are inferred from the claim text.