Systems and methods for delivery of a therapeutic agent
AssigneeThe Foundry, LLC
InventorsMark E. Deem, Hanson Gifford
Life of this patent
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Abstract
Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G botulinum toxins, via permeabilization of targeted cell membranes to enable translocation of the botulinum neurotoxin light chain (BoNT-LC) molecule across the targeted cell membrane to the cell cytosol where a therapeutic response is produced in a mammalian system. The methods and apparatus include use of catheter based delivery systems, non-invasive delivery systems, and transdermal delivery systems.
Claims18
Apparatus for treating tissue in a nasal cavity, the apparatus comprising:
- an elongate body, comprising:
- a proximal portion;
- and
- a distal portion configured for positioning in a nasal cavity;
- a first electrode comprising a first pair of electrodes and a second electrode comprising a second pair of electrodes, the first electrode and second electrode being spaced away from one another and coupled with the distal portion of the elengate body and configured to deliver energy to a target tissue in the nasal cavity;
- and
- a generator coupled with the proximal portion of the elongate body for supplying energy to at least one of the first electrode or the second electrode to treat the target tissue in the nasal cavity, the generator configured to deliver the energy in pulses between 1 V and 500 V.
Apparatus for treating tissue in a nasal cavity, the apparatus comprising:
- an elongate body, comprising:
- a proximal portion;
- and
- a distal portion configured for positioning in a nasal cavity;
- a first electrode comprising a first pair of electrodes and a second electrode comprising a second pair of electrodes, the first electrode and second electrode being spaced away from one another and coupled with the distal portion of the elongate body and configured to deliver energy to a target tissue in the nasal cavity;
- and
- a generator coupled with the proximal portion of the elongate body for supplying energy to at least one of the first electrode or the second electrode to treat the target tissue in the nasal cavity, the generator configured to deliver the energy in pulses between 1 V and 500 V,
- wherein the first electrode and the second electrode are configured to be activated with energy from the generator in a sequential manner.
Apparatus for treating tissue in a nasal cavity, the apparatus comprising:
- an elongate body, comprising:
- a proximal portion, and
- a distal portion configured for positioning in a nasal cavity,
- a first pair of electrodes and a second pair of electrodes being spaced away from one another at the distal portion of the elongate body and configured to deliver energy to a target tissue in the nasal cavity, and
- a generator coupled with the proximal portion of the elongate body for supplying radiofrequency energy to at least one of the first pair of electrodes or the second pair of electrodes to treat the target tissue in the nasal cavity, the generator configured to deliver the radiofrequency energy in pulses between 1 V and 500 V and for a duration between 5 microseconds to 100 milliseconds.
Dependencies are inferred from the claim text.