Method and device for detecting subclinical hypoxemia using whole blood T2P
AssigneeTexas Tech University System
InventorDavid P. Cistola
Life of this patent
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Abstract
The present disclosure pertain to methods of detecting hypoxemia in a subject by: (1) receiving a blood sample from the subject; (2) measuring the T2 relaxation time constant of the blood cell (e.g., blood cell pellet) of the blood sample (T2P value); and (3) correlating the measured T2P value to hypoxemia. The methods of the present disclosure also include a step of correlating the measured T2P value to the subject's susceptibility to one or more hypoxemia-related conditions. The present disclosure also pertains to systems for detecting hypoxemia in a subject in accordance with the methods of the present disclosure.
Claims21
A method of detecting hypoxemia in a subject, said method comprising:
- receiving a blood sample from the subject;
- measuring the T2 relaxation time constant of the blood cells of the blood sample (T2P value), wherein the T2P value represents the spin-spin relaxation time constant of the blood cell component of the blood sample, wherein the blood cell component is in the form of a pellet, and wherein the T2P value is represented by the following formula:
- I
-
- (
- t
- )
- =
- ∑
- i
- A
- i
-
- e
- -
- t
- /
- T
- 2
-
- i
- wherein I(t) represents the nuclear magnetic resonance (NMR) signal intensity, Ai represents the signal amplitude, and T2i represents the transverse relaxation time constant of ith proton microenvironment or mobility domain;
- and
- correlating the measured T2P value to hypoxemia.
A system for detecting hypoxemia in a subject, wherein the system comprises one or more computer-readable storage mediums having a program code embodied therewith, wherein the program code comprises programming instructions for:
- receiving a blood sample from the subject;
- measuring the T2 relaxation time constant of blood cells of the blood sample (T2P value), wherein the T2P value represents the spin-spin relaxation time constant of the blood cell component of the blood sample, wherein the blood cell component is in the form of a pellet, and wherein the T2P value is represented by the following formula:
- I
-
- (
- t
- )
- =
- ∑
- i
- A
- i
-
- e
- -
- t
- /
- T
- 2
-
- i
- wherein I(t) represents the nuclear magnetic resonance (NMR) signal intensity, Ai represents the signal amplitude, and T2i represents the transverse relaxation time constant of ith proton microenvironment or mobility domain;
- and
- correlating the measured T2P value to hypoxemia.
Dependencies are inferred from the claim text.