System and method for NMR analysis of a physiological condition in an analyte
AssigneesFundació Institut De Bioenginyeria De Catalunya, Institució Catalana De Recerca I Estudis AvançAts
InventorsIrene Marco Rius, Jose Yeste Lozano, Alba Herrero Gómez, Marc Azagra Rodríguez, Maria Alejandra Ortega Machuca, Javier Ramón Azcón
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Abstract
The disclosure relates to a system and a method of analysing a physiological condition in an analyte. In particular, the disclosure pertains to systems, components of such systems, and methods of analysing a physiological condition in an analyte using hyperpolarization (HP) and magnetic resonance (MR) techniques.
Claims16
A system for determining a physiological condition in at least one analyte using hyperpolarized (HP) nuclear magnetic resonance, the system at least comprising:
- a hyperpolarizing (HP) preparation apparatus structure to hyperpolarize a substrate agent;
- a sample matrix for containing an analyte,
- a microfluidic device provided with at least one measuring chamber structured to accommodate the sample matrix containing the analyte, the microfluidic device being structured to infuse the at least one analyte accommodated in the sample matrix with the hyperpolarized substrate agent;
- a NMR apparatus at least comprising a housing defining a target area for accommodating at least the analyte with the hyperpolarized substrate agent, as well as at least one magnet unit and at least one magnetic gradient unit for applying—during use—one or more magnetic field gradients in the target area, and at least one radiofrequency (RF) pulse generation unit for applying one or more sets of RF pulses towards the target area, and a RF receiving unit for acquiring signals, and
- a computer processing unit for determining the physiological condition in the analyte by analysing the acquired signals.
Dependencies are inferred from the claim text.