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US 12,429,485 B2Granted
Biomarker panels for on-treatment prediction of response to immuno-oncology drugs
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsAlissa Keegan, David R. Walt, Limor Cohen
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Abstract
Biomarker panels for the prediction of patient response to immunotherapy, and methods of use thereof.
Claims18
A method comprising:
- obtaining an initial sample comprising blood from a human subject who has lung cancer;
- administering to the human subject at least one dose of an antibody that binds to programmed cell death protein 1 (PD-1) or an antibody that binds to programmed cell death 1 ligand 1 (PD-L1);
- obtaining a subsequent sample of blood from the human subject;
- measuring a level of interleukin 6 (IL-6) in the initial sample and the subsequent sample using an ultrasensitive protein detection technology;
- comparing the levels of IL-6 in the initial sample and the subsequent sample;
- and
- (a) administering to the human subject further doses of the antibody if the subsequent sample has decreased levels of IL-6 as compared to the initial sample, or
- (b) administering to the human subject at least one therapy with or without further doses of the antibody if the subsequent sample has increased levels or no change in levels of IL-6 as compared to the initial sample.
5 more elements
Dependencies are inferred from the claim text.