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US 12,429,483 B2Granted
System and method for determining onset and disease progression
AssigneeRespiration Scan Ltd
InventorsYaron Lapidot, Igal Moshe Bar Ilan
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Abstract
The invention disclosed herein concerns screening and early detection of a variety of disease conditions in seemingly healthy subjects, enabling early intervention and treatment.
Claims22
A method for identifying in a breath sample from a subject an early onset of a bacterial disease state and treating the bacterial disease state by detecting the presence of at least one disease-associated cluster of volatile compounds indicative of the bacterial disease, the method comprising;
- at a first time, exposing a first breath sample of the subject to at least one first sampling unit comprising one or more adsorbing regions capable of reversibly associating volatile compounds in said breath sample, the adsorbing region being different from a metallic surface or metallic nanoparticle, desorbing adsorbed compounds, analyzing an identity of the adsorbed compounds after desorbing the adsorbed compounds, and determining a level of the at least one disease-associated cluster of volatile compounds;
- at an at least one consequent further time point, exposing a breath sample of the subject to a further sampling unit comprising one or more adsorbing regions capable of reversibly associating to volatile compounds in said breath sample, desorbing a adsorbed compounds, analyzing an identity of the adsorbed compounds after desorbing the adsorbed compounds, and determining a level of the at least one disease-associated cluster of volatile compounds;
- comparing the level of the cluster of volatile compounds associated with said disease of said at least one first sampling unit and the level of said further sampling unit;
- wherein an increase or a decrease of at least 50% in the level associated with the further sampling unit compared to that of the first sample unit is indicative of the early onset of said disease state;
- and
- responsive to comparing the level of the cluster of volatile compounds, beginning a therapeutic treatment or modifying the therapeutic treatment.
3 more elements
A method for determining an onset of ventilator-associated pneumonia (VAP) in a ventilated subject and treating the ventilated subject, the method comprising;
- at a first time point, exposing a first breath sample from the ventilated subject to at least one first sampling unit comprising one or more adsorbing regions capable of reversibly associating to volatile compounds in said first breath sample, desorbing adsorbed compounds, analyzing an identity of the adsorbed compounds after desorbing the adsorbed compounds, and determining a level of at least one disease-associated cluster of volatile compounds;
- at an at least one consequent further time point, exposing a breath sample from the ventilated subject to a further sampling unit comprising one or more adsorbing regions capable of reversibly associating to volatile compounds in said breath sample, desorbing adsorbed compounds, analyzing an identity of the adsorbed compounds after desorbing the adsorbed compounds, and determining the level of the at least one disease-associated cluster of volatile compounds;
- comparing the level of the cluster of volatile compounds of a VAP-causing pathogen of said at least one first sampling unit and the level of said further sampling unit, wherein the VAP-causing pathogen is a bacterium;
- wherein increase or a decrease of at least 50% in the level associated with the further sampling unit compared to that of the first sample unit is indicative of an early of onset of VAP;
- and
- responsive to comparing the level of the cluster of volatile compounds, beginning a therapeutic treatment or modifying the therapeutic treatment.
3 more elements
Dependencies are inferred from the claim text.