Embossed film bioprocessing containers and integrity testing of bioprocessing containers
AssigneeEMD Millipore Corporation
InventorsBrian Pereira, Stephen Proulx
Life of this patent
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Abstract
A testing method that includes the steps of evacuating air from a container to a negative atmospheric pressure, the container being a collapsible, flexible container, and comprising at least two opposing flexible walls, wherein a surface of at least one of the walls internal to the container comprises a plurality of channels or recessed features on said at least one wall and monitoring a mass flow or a state of vacuum so as to determine the integrity of the container. The container can be of any size or conformation, with or without attached fittings.
Claims13
A method for integrity testing a collapsible, flexible bioprocessing container using a system, the method comprising:
- a) providing a collapsible, flexible bioprocessing container, wherein the container comprises at least two opposing flexible walls, wherein the surface of the walls internal to the container comprise a plurality of channels on said walls;
- b) evacuating air from the container and a reference tank connected to the container to a negative atmospheric pressure;
- c) sealing the system, the system comprising the container, the tank, and a tester between the container and the tank;
- and
- d) monitoring vacuum decay in the system using the tester, so as to determine the integrity of the container.
A method of detecting a 2 micron or larger defect in a collapsible, flexible bioprocessing container, the method comprising:
- a) providing a collapsible, flexible bioprocessing container, the container comprising at least two opposing flexible walls, wherein the surface of the walls internal to the container comprise a plurality of channels on said walls;
- b) evacuating air from the container and a reference tank connected to the container to a negative atmospheric pressure;
- c) sealing the system, the system comprising the container, the tank, and a tester between the container and the tank;
- and
- d) monitoring vacuum decay of the system using the tester, wherein an increase in mass flow indicates the presence of a defect.
Dependencies are inferred from the claim text.