Virus-like particles which can be used in the treatment of allergies
AssigneesSorbonne Universite, Inserm (Institut National De La Sante Et De La Recherche Medicale), Assistance Publique-Hopitaux de Paris
InventorsBertrand Bellier, David Klatzmann
Life of this patent
Estimating the term…
Abstract
The invention relates to a virus-like particle comprising an allergen and an immunoregulatory molecule exposed on its surface. The invention also relates to the use of said particle in the treatment of an allergy.
Claims13
A synthetic retroviral particle comprising an antigen and an immunoregulatory molecule exposed on the surface of the synthetic retroviral particle, said antigen being an allergen, wherein the immunoregulatory molecule exerts suppressive functions on antigen presenting cells, thereby promoting recruitment of regulatory T cells, and the immunoregulatory molecule is linked to the transmembrane glycoprotein domain of vesicular stomatitis virus (VSV-G) or to the glycophosphatidylinositol (GPI) anchoring domain of the CD59 glycoprotein.
Dependencies are inferred from the claim text.