Anti-Claudin 18.2 antibody and application thereof
AssigneesJiangsu Hengrui Medicine Co., Ltd., Shanghai Hengrui Pharmaceutical Co., Ltd.
InventorsYang Yang, Hu Ge, Weikang Tao
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Abstract
The present disclosure relates to an anti-Claudin 18.2 antibody and an application thereof. Specifically, the present invention relates to an anti-Claudin 18.2 antibody; a mouse-derived antibody, chimeric antibody, humanized antibody and antigen-binding fragment thereof which contain a CDR of the anti-Claudin 18.2 antibody, and a use thereof as a medicine. In particular, the present disclosure relates to a use of the anti-Claudin 18.2 antibody in the preparation of a drug for treating Claudin 18.2 positive diseases or disorders.
Claims17
An anti-Claudin 18.2 antibody comprising a heavy chain variable region and a light chain variable region, wherein:
- i) the heavy chain variable region comprises HCDR1, HCDR2 and HCDR3 as shown in SEQ ID NO:
- 15, SEQ ID NO:
- 16 and SEQ ID NO:
- 17, respectively, and
- the light chain variable region comprises LCDR1, LCDR2 and LCDR3 as shown in SEQ ID NO:
- 18, SEQ ID NO:
- 19 and SEQ ID NO:
- 20, respectively;
- or
- ii) the heavy chain variable region comprises HCDR1, HCDR2 and HCDR3 as shown in SEQ ID NO:
- 9, SEQ ID NO:
- 10 and SEQ ID NO:
- 11, respectively, and
- the light chain variable region comprises LCDR1, LCDR2 and LCDR3 as shown in SEQ ID NO:
- 12, SEQ ID NO:
- 13 and SEQ ID NO:
- 14, respectively.
Dependencies are inferred from the claim text.