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US 12,428,466 B2Granted
IL4/IL13 receptor molecule for veterinary use
AssigneeElanco US Inc.
InventorsHangjun Zhan, Lam Nguyen, Fawn Qian, Shyr Jiann Li
Life of this patent
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Abstract
Provided are various embodiments relating to IL13R/IL4R heterodimeric proteins derived from companion animal species and that bind to IL13 and/or IL4. Such heterodimeric proteins can be used in methods to treat IL13 and/or IL4-induced conditions in companion animals, such as canines, felines, and equines.
Claims18
A heterodimeric protein comprising:
- a) a first contiguous polypeptide comprising at least one IL13R extracellular domain (ECD) and a first Fc polypeptide,
- wherein the amino acid sequence of the at least one IL13R ECD is SEQ ID NO:
- 22, SEQ ID NO:
- 24, SEQ ID NO:
- 26, SEQ ID NO:
- 32, or SEQ ID NO:
- 34, SEQ ID NO:
- 36, and
- b) a second contiguous polypeptide comprising at least one IL4R ECD and a second Fc polypeptide,
- wherein the amino acid sequence of the at least one IL4R ECD is SEQ ID NO:
- 23, SEQ ID NO:
- 25, SEQ ID NO:
- 27, SEQ ID NO:
- 33, SEQ ID NO:
- 35, or SEQ ID NO:
- 37, wherein the IL13R ECD and/or the IL4R ECD are derived from a companion animal species.
13 more elements
A heterodimeric protein comprising:
- a) a first polypeptide comprising at least one IL13R extracellular domain (ECD) and a first Fc polypeptide, and
- b) a second polypeptide comprising at least one IL4R ECD and a second Fc polypeptide;
- wherein the IL13R ECD and/or the IL4R ECD are derived from a canine;
- wherein the IL13R ECD sequence is SEQ ID NO:
- 22;
- wherein the IL4R ECD sequence is SEQ ID NO:
- 23;
- wherein the first polypeptide is SEQ ID NO:
- 103;
- wherein the second polypeptide is SEQ ID NO:
- 102;
- wherein the first Fc polypeptide is SEQ ID NO 55;
- and
- wherein the second Fc polypeptide is SEQ ID NO 59.
11 more elements
Dependencies are inferred from the claim text.