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US 12,428,441 B2Granted
Modified nucleoside phosphoramidites
AssigneeJanssen BioPharma, Inc.
InventorsSergei Gryaznov, Jin Hong, Vivek Kumar Rajwanshi, Leonid Beigelman
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Abstract
The present disclosure relates to compounds and compositions containing 5′-phosphoramidite nucleoside monomers, and methods of making and use.
Claims18
A compound represented by Formula (II):
- wherein
- X is O;
- Z is H;
- B is a nucleobase selected from the group consisting of adenine (A), guanine (G), cytosine (C), uracil (U), 6-N-benzoyladenine (ABz), 4-N-benzoylcytosine (CBz), and 2-N-isobutyrylguanine (GiBu);
- each R1 is independently C1-6 alkyl or C3-6 cycloalkyl;
- R2 is —CH2CH2CN or C1-6 alkyl;
- or one R1 and R2 together form an optionally substituted heterocycloalkyl ring comprising one to six carbon atoms;
- R3 is H or an alcohol protecting group selected from the group consisting of tert-butyldimethylsilyl (TBMDS), tert-butyldiphenylsilyl (TBDPS), tnisopropylsilyl (TIPS), trityl, monomethoxytrityl (MMTr), and tritolyl;
- A is —(CR′R′)1-2—;
- and
- each R′ is independently H or Me.
8 more elements
A compound selected from:
Dependencies are inferred from the claim text.