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US 12,428,410 B2Granted
Use of small molecule inhibitors to KLF10 for modulation of T regulatory cells and cancer immunotherapy
AssigneesThe Brigham and Women's Hospital, Inc., Beth Israel Deaconess Medical Center, Inc.
InventorsMark Feinberg, Santosh A. Khedkar
Life of this patent
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Abstract
The invention relates to compositions and methods for inhibiting Krüppel-like Factor 10 (KLF10) for modulation of T regulatory cells and cancer immunotherapy.
Claims8
A composition comprising:
- (i) one or more disease antigens or a vaccine;
- and (ii) a compound of formula:
- wherein:
- (a)
- R2 is selected from H, OH, CH3, and OCH3;
- R4 is selected from H, OH, and OCH3;
- R5 is selected from H, CH3, and C2H5;
- R2′ is selected from H and OH;
- R3′ is selected from H and OCH3;
- R4′ is selected from H, CH3, C2H5, CH(CH3)2, OCH3, Ph, F, and I;
- and
- R5′ is selected from H, CH3, and OCH3;
- or
- R3′ and R4′ can be taken together as CH═CH—CH═CH;
- or
- R4′ and R5′ can be taken together as CH═CH—CH═CH, or
- wherein two of R2, R4, and R5 may be optionally connected, and two of R2′, R3′, R4′, and R5′ may be optionally connected;
- or
- (b)
- R2 is selected from H, OH, CH3, and OCH3;
- R4 is selected from H, OH, and OCH3;
- R5 is H;
- R2′ is selected from H and OH;
- R3′ is selected from H and OCH3;
- R4′ is selected from H, CH3, C2H5, OCH3, Ph, F, and I;
- and
- R5′ is selected from H;
- or
- R3′ and R4′ can be taken together as CH═CH—CH═CH;
- or
- R4′ and R5′ can be taken together as CH═CH—CH═CH, or
- wherein two of R2, R4, and R5 may be optionally connected, and two of R2′, R3′, R4′, and R5′ may be optionally connected.
29 more elements
Dependencies are inferred from the claim text.