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US 12,428,408 B2Granted
Fused heterocyclic mescaline derivatives
AssigneeEnveric Biosciences Canada Inc.
InventorsPeter J. Facchini, Jillian M. Hagel, Chang-Chun Ling, Ye Cai, David James Press, Glynnis Elizabeth Jensen, Jessica Bik-Jing Lee, Kaveh Matinkhoo
Life of this patent
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Abstract
Disclosed are novel fused heterocyclic mescaline derivative compounds, notably fused heterocyclic mescaline derivatives and pharmaceutical and recreational drug formulations containing the same. Methods of making and using these compounds are also disclosed.
Claims19
A chemical compound selected from a first chemical compound having chemical formula (I), and a second chemical compound having chemical formula (II):
- wherein, in each chemical formula (I) and (II)
- R1 is an optionally substituted alkylene group having 1-3 carbon atoms or a carbonyl group (—C(═O));
- X1 and X2 are independently selected from an oxygen atom, a sulfur atom, —NH, or an N-alkyl group, and X3, X4, or X5 are independently a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group, an acyl group, an amino group, an N-substituted amino group, an amide group, a substituted amide group, a substituted amido group, a hydroxy group, a cyano group, a carboxy group, a thiol group, or a thioether group, and wherein two or three of X3, X4, or X5 are a hydrogen atom;
- R3 is a methyl group, a cyano group, or a hydrogen atom;
- and
- R4 and R5 are independently selected from an alkyl group, an alkoxy group, a hydroxyalkyl group, an N-substituted amino group, an alkyl-heteroaryl group wherein the heteroaryl is optionally substituted, or a hydrogen atom, and wherein at least one of R4 and R5 is an alkyl-aryl group, wherein the aryl group is substituted by being fused to a 5 or 6 membered heterocyclic ring containing two oxygen atoms, and wherein the aryl group is additionally substituted with a halogen atom, wherein further the amino group (—NR4R5) in each of compounds of formula (I) and (II) is optionally protonated to form (—N+HR4R5), and chemical formula (I) or (II) further includes a negatively charged anion balancing the positively charged nitrogen atom.
3 more elements
Dependencies are inferred from the claim text.